About

Unlocking the Secrets of Primary Cilia Dynamics

FOR5547 is a research group dedicated to analyzing the dynamics of primary cilia in various tissue types. With seven projects focused on understanding the role of intraciliary molecules, extracellular stimuli, and molecular mechanisms, we aim to uncover the mechanisms that control tissue development and function.

Our GOALS are to dissect primary cilia dynamics in a collaborative approach to get a better understanding about the role of primary cilia dynamics in controlling tissue organization and function. We are focusing on the dynamic composition of proteins within the cilium and how those proteins enable the dynamic sensing of signals resulting in a local signal transduction. Finally, we want to shed light about the dynamic assembly and disassembly of primary cilia.

Central Questions

How do intracilary protein dynamics control ciliary functions to determine cell fate and tissue organization?
How do extracellular stimuli regulate primary cilia dynamics to control cell fate and function?
What are the molecular mechanisms underlying primary cilia assembly and disassembly?
What are the molecular mechanisms underlying changes in ciliary signaling dynamics that regulate tissue organization?

Discover

Scientific background and project overview

Defining dynamics of intraciliary molecules

Projects P1, P2, and P3 focus on understanding how the dynamics of intraciliary molecules control cell fate, morphogenesis, and tissue organization.

Revealing intraciliary signaling

Projects P4 and P5 investigate how extracellular stimuli regulate the dynamics of primary cilia, controlling cell fate and function.

Uncovering cilia-dependent tissue organization

P6 and P7 aims to identify the molecular mechanisms underlying how dynamics of primary cilia assembly and disassembly and dynamics in ciliary signaling regulate tissue organization.

Expertise

Meet our Team

The research unit consist of researchers across Germany who will build up a network by sharing their experimental and theoretical comprehension. Together with their expertise on the different approaches from in vitro to in vivo work, they will strengthen the ciliary research to achieve their goal.